Acetic Anhydride → N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

HRID 1862829노트

반응식

HRID 1862829 반응식
[NH2:1][C:2]1[NH:3][C:4](=[O:10])[CH:5]([CH3:9])[C:6](=[O:8])[N:7]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(O)(=O)C>[C:11]([NH:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]([CH3:9])[C:4](=[O:10])[N:3]=1)(=[O:13])[CH3:12]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 27247262-amino-5-methyl-1H-pyrimidine-4,6-dione

생성물 1

HCID 20393810N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

80 parts of 2-amino-4,6-dioxo-5-methyl-pyrimidine are treated for 8 hours under reflux in a mixture comprising 500 parts by volume of acetic acid and 108 parts by volume of acetic anhydride. 87 parts of the desired product are obtained by filtration, washing with ether and drying in vacuo.

출처 및 근거

ORD 기록
ord-d6c4d46621f341e6a7072144e29143c3
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04166852

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