Dimethylcarbamoyl Chloride → Carbamic acid, dimethyl-, 2,6-dimethyl-4-pyridinyl ester

HRID 1863210

반응식

HRID 1863210 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:16][N:17]([CH3:21])[C:18](Cl)=[O:19]>C(#N)C>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][C:18]([N:17]([CH3:21])[CH3:16])=[O:19])[CH:5]=[C:4]([CH3:9])[N:3]=1

참가 물질

5

반응물 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 11430Potassium CarbonateHCID 178429033HCID 178429033, 화합물

생성물 1

HCID 19112Carbamic acid, dimethyl-, 2,6-dimethyl-4-pyridinyl ester

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
80 °C

실험 절차

30,8 g (0,25 mole) of 2,6-dimethyl-4-hydroxypyridine were suspended in 500 ml of acetonitrile, 69 g (0,5 mole) of potassium carbonate were added and the mixture was heated to reflux temperature for 2 hours. Subsequently 47 g (0,44 mole) of dimethylcarbamic acid chloride were added at an interior temperature of approximately 60°-70° C. and the mixture was maintained for two hours at about 80° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux temperature for 2 hours

출처 및 근거

ORD 기록
ord-0d7f368c27a0473eb24cf27cb4e322ef
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04168311

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