3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1863617

반응식

HRID 1863617 반응식
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC(C)(C)N=P(N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)C(C)(C)C)c(C(C)C)c1.CS(=O)(=O)O.CS(C)=O.Nc1ccccc1-c1[c-]cccc1.[Pd]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

참가 물질

6

반응물 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

생성물 1

HCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine

시약·촉매·용매 3

HCID 3856267tert-Butylimino-tri(pyrrolidino)phosphorane시약HCID 90645613(2'-Amino-2-biphenylyl)palladium(1+) methanesulfonate-bis(2-methyl-2-propanyl)(2',4',6'-triisopropyl-2-biphenylyl)phosphine (1:1:1)촉매HCID 679Dimethyl Sulfoxide용매4회

후처리

  1. additionsolution of bipheny (3%) and acetic acid to quench reaction. Acetic acid amount not specified.
  2. aliquot기록된 절차가 없습니다
  3. addition기록된 절차가 없습니다

출처 및 근거

ORD 기록
ord-629dd2001b21472c9eca28514e61dd1f
출처 데이터셋
Pd-catalyzed Buchwald-Hartwig C-N cross-coupling
원본 링크
출처 보기

연결된 노트

불러오는 중…