3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1863710

반응식

HRID 1863710 반응식
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)C(C)(C)C)c(C(C)C)c1.CN1CCCN2CCCN=C12.CS(=O)(=O)O.CS(C)=O.Nc1ccccc1-c1[c-]cccc1.[Pd]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

참가 물질

6

반응물 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

생성물 1

HCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine

시약·촉매·용매 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene시약HCID 90645613(2'-Amino-2-biphenylyl)palladium(1+) methanesulfonate-bis(2-methyl-2-propanyl)(2',4',6'-triisopropyl-2-biphenylyl)phosphine (1:1:1)촉매HCID 679Dimethyl Sulfoxide용매4회

후처리

  1. additionsolution of bipheny (3%) and acetic acid to quench reaction. Acetic acid amount not specified.
  2. aliquot기록된 절차가 없습니다
  3. addition기록된 절차가 없습니다

출처 및 근거

ORD 기록
ord-8e3830534cf742078ea3c15f6c1d5f26
출처 데이터셋
Pd-catalyzed Buchwald-Hartwig C-N cross-coupling
원본 링크
출처 보기

연결된 노트

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