Hydrochloric Acid → HCID 87483712, 화합물

HRID 1863952노트

반응식

HRID 1863952 반응식
C(OC(=O)[NH:7][C@H:8]([CH2:27][C:28]1[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=1[F:36])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1)(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[F:36][C:29]1[CH:30]=[C:31]([F:35])[C:32]([F:34])=[CH:33][C:28]=1[CH2:27][C@@H:8]([NH2:7])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:24])([F:26])[F:25])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 90695481HCID 90695481, 화합물

생성물 1

HCID 87483712HCID 87483712, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To 47 mg (0.89 mmol) of tert-butyl{(1R)-1-(2,4,5-trifluorobenzyl)-2-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4′,3′:1,2]pyrido[3,4-d]pyrimidin-3-yl]ethyl}carbamate was added 1.8 mL of 4M HCl in anhydrous dioxane. The mixture was stirred at room temperature for 30 minutes and then concentrated. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 429 (M+1).

후처리

  1. concentrationconcentrated
  2. washThe residue was washed with diethyl ether
  3. customdried

출처 및 근거

ORD 기록
ord-e1d287dcad2146fb94e045a132434b34
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625888B2

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