Hydrochloric Acid → 2-Amino-N-(2-hydroxyethyl)benzamide

HRID 1864041노트

반응식

HRID 1864041 반응식
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[CH2:13]([CH2:15][NH2:16])[OH:14].Cl>O>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:16][CH2:15][CH2:13][OH:14])=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 700EthanolamineHCID 8359Isatoic Anhydride

생성물 1

HCID 30164842-Amino-N-(2-hydroxyethyl)benzamide수율 71.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A round-bottomed flask was charged with isatoic anhydride (5.0 g, 0.030 mol) and 40 mL water. Ethanolamine (2.21 mL, 0.036 mol) was added slowly to the reaction mixture. The reaction mixture was acidified with 1N HCl and extracted with EtOAc. The aqueous layer was basified with 6N NaOH and extracted with EtOAc. The EtOac layer was dried over Na2SO4, filtered, and concentrated to dryness to afford 2-amino-N-(2-hydroxyethyl)benzamide (3.86 g, 70%).

후처리

  1. extractionextracted with EtOAc
  2. extractionextracted with EtOAc
  3. dry with materialThe EtOac layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-4173bff4a4954617b3adcf05079719aa
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625903B2

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