1-(3-(Trifluoromethyl)phenyl)piperazine → (RS)-1-(3-Methoxy-benzenesulfonyl)-3-phenyl-4-[4-(3-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-imidazolidin-2-one

HRID 1864369

반응식

HRID 1864369 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:12]2[CH2:16][CH:15]([C:17]([OH:19])=O)[N:14]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:13]2=[O:26])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.[F:27][C:28]([F:42])([F:41])[C:29]1[CH:30]=[C:31]([N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:32]=[CH:33][CH:34]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:12]2[CH2:16][CH:15]([C:17]([N:38]3[CH2:37][CH2:36][N:35]([C:31]4[CH:32]=[CH:33][CH:34]=[C:29]([C:28]([F:41])([F:42])[F:27])[CH:30]=4)[CH2:40][CH2:39]3)=[O:19])[N:14]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:13]2=[O:26])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 67141122(RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acid

생성물 1

HCID 25027710(RS)-1-(3-Methoxy-benzenesulfonyl)-3-phenyl-4-[4-(3-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-imidazolidin-2-one

실험 절차

In analogy to example 1, (RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acid (step 4 of example 1) was reacted with N-(3-trifluoromethylphenyl)-piperazine to give the title compound as a colorless solid. MS: 588.5 ([M+H]+)

출처 및 근거

ORD 기록
ord-75f78c18f62f4916981b147fe201158d
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625902B2

연결된 노트

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