Ammonium formate → HCID 68749290, 화합물
반응식
[CH3:1][Si:2]([CH3:16])([CH3:15])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7].C([O-])=O.[NH4+:20]>[Pd].O.CO>[CH3:1][Si:2]([CH3:16])([CH3:15])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH2:20])[CH2:10][CH2:9]1)=[O:7]참가 물질
6
실험 절차
A slurry of 10% palladium on carbon (200 mg) in water was added to 4-oxo-piperidine-1-carboxylic acid-2-trimethylsilanyl-ethyl ester (2.42 g, 10 mmol) in 100 mL of methanol. Ammonium formate (6.0 g, 95 mmol) in water was added dropwise, and the mixture stirred vigorously overnight. The mixture was filtered and the filtrate concentrated in vacuo to leave the crude product. Chromatography (elution with methanol-dichloromethane) provided 0.98 g of product.
후처리
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated in vacuo
- customto leave the crude product
- washChromatography (elution with methanol-dichloromethane)
출처 및 근거
- ORD 기록
- ord-e09efe30857045cbbddb93b978dbd682
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07625889B2
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