Trifluoroacetic acid → Methyl (3-bromo-4-nitrophenyl)acetate

HRID 1864958노트

반응식

HRID 1864958 반응식
[CH3:1][O:2][C:3](=[O:22])[CH:4]([C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[C:14]([Br:21])[CH:13]=1)C(OC(C)(C)C)=O.FC(F)(F)C(O)=O.C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:22])[CH2:4][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[C:14]([Br:21])[CH:13]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 576832692-(3-Bromo-4-nitrophenyl)malonic acid tert-butyl ester methyl ester

생성물 1

HCID 23512304Methyl (3-bromo-4-nitrophenyl)acetate수율 94.9%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The 2-(3-bromo-4-nitrophenyl)malonic acid tert-butyl ester methyl ester (1.18 g) obtained in Example 4 a) was dissolved in chloroform (10 mL), trifluoroacetic acid (10 g) was added thereto under ice-cooling, and the mixture was stirred at room temperature for 5 hours. The reaction mixture was poured gradually into ice and saturated aqueous sodium bicarbonate, and extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over sodium sulfate and concentrated to give the title compound (0.820 g) as a pale yellow oil.

후처리

  1. temperatureunder ice-cooling
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water and saturated brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5771433f77cc468d8cb9a0f12a34bf4e
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625948B2

반응 노트

불러오는 중…