4-Morpholinecarbonyl chloride → 5-Bromo-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-[(morpholinocarbonyl)oxy]-benzamide

HRID 1865376

반응식

HRID 1865376 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:22])=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=1[Cl:20])=[O:8].[N:23]1([C:29](Cl)=[O:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][C:29]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[O:30])=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:17])([F:19])[F:18])=[CH:12][C:11]=1[Cl:20])=[O:8]

참가 물질

3

반응물 2

HCID 848104-Morpholinecarbonyl chlorideHCID 178602905-Bromo-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-hydroxybenzamide

생성물 1

HCID 696645545-Bromo-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-[(morpholinocarbonyl)oxy]-benzamide수율 93.5%

실험 절차

Using 5-bromo-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-hydroxybenzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

출처 및 근거

ORD 기록
ord-6636d081322d4c95b129abfa807cf2a1
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07626042B2

연결된 노트

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