4-Morpholinecarbonyl chloride → HCID 86604727, 화합물

HRID 1865385노트

반응식

HRID 1865385 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:26])=[C:6]([CH:25]=1)[C:7]([NH:9][C:10]1[S:11][C:12]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[N:14]=1)=[O:8].[N:27]1([C:33](Cl)=[O:34])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:26][C:33]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:34])=[C:6]([CH:25]=1)[C:7]([NH:9][C:10]1[S:11][C:12]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:13]([C:15]([CH3:18])([CH3:16])[CH3:17])[N:14]=1)=[O:8]

참가 물질

3

반응물 2

HCID 848104-Morpholinecarbonyl chlorideHCID 9843610HCID 9843610, 화합물

생성물 1

HCID 86604727HCID 86604727, 화합물수율 93.1%

실험 절차

Using 5-chloro-N-{4-[(1,1-dimethyl)ethyl]-5-[(2,2-dimethyl)propionyl]-thiazol-2-yl}-2-hydroxybenzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

출처 및 근거

ORD 기록
ord-380d1f777e4a4ebda301d0b068fcffb6
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07626042B2

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