Methanol → 7-Methoxyquinoline-3-carboxylic acid
반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]([O:15]CC)=[O:14])[CH:9]=[N:10]2)=[CH:5][CH:4]=1.CO.[OH-].[Na+]>C1COCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]([OH:15])=[O:14])[CH:9]=[N:10]2)=[CH:5][CH:4]=1참가 물질
5
실험 절차
To a solution of the intermediate from step C (399 mg, mmol) in THF (6 mL) was added methanol (1 mL) followed by NaOH (5N, 1.5 mL). After stirring at room temperature for 18 hours the reaction was concentrated in vacuo. The residue was acidified with 1N HCl (10 mL). The solution was concentrated in vacuo and azeotroped with toluene (4×). This material was used in the next step without any further purification.
후처리
- concentrationwas concentrated in vacuo
- concentrationThe solution was concentrated in vacuo
- customazeotroped with toluene (4×)
- customThis material was used in the next step without any further purification
출처 및 근거
- ORD 기록
- ord-22146aec56cb4f5692070cd8f65af8cd
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07625938B2
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