Triphenylphosphine → (S)-2-phenyl-1-(thiazol-2-yl)ethanamine

HRID 1865707노트

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HRID 1865707 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:20]1([CH2:26][C@H:27]([N:33]=[N+]=[N-])[C:28]2[S:29][CH:30]=[CH:31][N:32]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[OH-].[NH4+]>O1CCCC1.O>[C:20]1([CH2:26][C@H:27]([NH2:33])[C:28]2[S:29][CH:30]=[CH:31][N:32]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

6

반응물 3

HCID 11776TriphenylphosphineHCID 14923Ammonium HydroxideHCID 10955374(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethylazide

생성물 1

HCID 10198148(S)-2-phenyl-1-(thiazol-2-yl)ethanamine

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

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온도
55 °C

실험 절차

To a 55° C. (oil bath) solution of triphenylphosphine (1.6 g, 6.3 mmol) in tetrahydrofuran (10 mL) is added (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethylazide (contaminated with DPPA, 1.2 g, 5.2 mmol) as a solution in tetrahydrofuran (10 mL). The reaction mixture is allowed to stir for 2 hours at this temperature when aqueous ammonium hydroxide (14 mL) is added. Stirring at 55° C. is continued for 3 hours before the reaction mixture is stored in a −5° C. freezer overnight. The next morning, the reaction mixture is diluted with water (80 mL) and extracted twice with diethyl ether. The combined extracts are washed with 10% aqueous hydrochloric acid (70 mL). The acidic aqueous phase is cooled in an ice-water bath and then basified with 10% aqueous sodium hydroxide to pH 12. The basic phase is then extracted thrice with dichloromethane. The combined extracts are dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure to provide a 0.67 g (52% over 2 steps) of a slightly blond oil. MS (ES+): (M+H)=205.0

후처리

  1. additionis added
  2. waitis stored in a −5° C. freezer overnight
  3. extractionextracted twice with diethyl ether
  4. washThe combined extracts are washed with 10% aqueous hydrochloric acid (70 mL)
  5. temperatureThe acidic aqueous phase is cooled in an ice-water bath
  6. extractionThe basic phase is then extracted thrice with dichloromethane
  7. dry with materialThe combined extracts are dried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. concentrationconcentrated under reduced pressure
  10. customto provide a 0.67 g (52% over 2 steps) of a slightly blond oil

출처 및 근거

ORD 기록
ord-d0d71a31fa5547b6a764ce144b612129
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07626023B2

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