4-Bromobenzoic acid → 4-bromo-N-cyclopropylbenzamide

HRID 1865858

반응식

HRID 1865858 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.CN(C(ON1N=NC2[CH:22]=[CH:23][CH:24]=[N:25]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.C1(N)CC1>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:25][CH:24]2[CH2:22][CH2:23]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

6

반응물 4

HCID 114644-Bromobenzoic acidHCID 69828CyclopropylamineHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 8829494-bromo-N-cyclopropylbenzamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Bromo-benzoic acid (2.5116 g, 12.5 mmol) and HATU (5.2213 g, 13.7 mmol) were dissolved in DMF (40 mL). DIEA (4.572 mL, 26.2 mmol) was added, and the mixture was allowed to stir at ambient temperature for 15 minutes. Then cyclopropylamine (0.866 mL, 12.5 mmol) was added, and the reaction was stirred at ambient temperature overnight. The solvent was removed, and the crude was purified via silica gel chromatography to give the desired product.

후처리

  1. stirringthe reaction was stirred at ambient temperature overnight
  2. customThe solvent was removed
  3. customthe crude was purified via silica gel chromatography

출처 및 근거

ORD 기록
ord-369d6c7334354de583302be9023cabc1
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07629340B2

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