Sodium Hydroxide → 6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetic acid

HRID 1865904

반응식

HRID 1865904 반응식
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:11][C:12]([O:14]CC)=[O:13])[N:9]=[CH:10][C:5]2=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[N:3]=1.[OH-].[Na+]>CO>[NH2:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:11][C:12]([OH:14])=[O:13])[N:9]=[CH:10][C:5]2=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22015527ethyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetate

생성물 1

HCID 220155316-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetic acid수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of ethyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidin-1-ylacetate (350 mg, 1.22 mmol) in MeOH (2 mL) was treated with NaOH (1-M, 1 mL, 1 mmol), refluxed for 15 min, cooled, acidified and filtered to give the title compound (300 mg, 95%) as a white solid.

후처리

  1. temperaturerefluxed for 15 min
  2. temperaturecooled
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-bf18688fd35e482985b9d096ba7964f3
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07629349B2

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