Ammonium formate → HCID 178448358, 화합물

HRID 1866752

반응식

HRID 1866752 반응식
[CH3:1][CH:2]([C@H:4]([NH2:23])[C:5]([O:7][CH2:8][CH2:9][O:10][CH2:11][N:12]1[C:16]2[NH:17][C:18]([NH2:22])=[N:19][C:20](=[O:21])[C:15]=2[N:14]=[CH:13]1)=[O:6])[CH3:3].[CH:24]([O-])=[O:25].[NH4+]>CN1CCCC1=O>[CH3:3][CH:2]([C@H:4]([NH:23][CH:24]=[O:25])[C:5]([O:7][CH2:8][CH2:9][O:10][CH2:11][N:12]1[C:16]2[NH:17][C:18]([NH2:22])=[N:19][C:20](=[O:21])[C:15]=2[N:14]=[CH:13]1)=[O:6])[CH3:1]

참가 물질

4

반응물 2

HCID 2723923Ammonium formateHCID 178448382HCID 178448382, 화합물

생성물 1

HCID 178448358HCID 178448358, 화합물

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
125 °C

실험 절차

A 100 ml round bottom flask equipped with magnetic stir bar is charged with 7.25 gr Valacyclovir (20 mmol), 1.97 gr ammonium formate (31.2 mmol), NMP (N-Methyl-pyrrolidone) (15 ml) is added and stirring is started. The resulting mixture is placed in an oil bath that is heated to 125° C. for 2 hrs. The mixture is removed from the oil bath, allowed to cool to room temperature, and the solvent is removed under reduced pressure using high vac. pump. The residue is crystallized from 150 ml boiling water to give 6.0 gr at the purity of 80%.

후처리

  1. customA 100 ml round bottom flask equipped with magnetic stir bar
  2. additionis added
  3. customThe resulting mixture is placed in an oil bath
  4. customThe mixture is removed from the oil bath
  5. temperatureto cool to room temperature
  6. customthe solvent is removed under reduced pressure
  7. customThe residue is crystallized from 150 ml
  8. customto give 6.0 gr at the purity of 80%

출처 및 근거

ORD 기록
ord-43fa7e8655014d38a105c0e79732f646
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07629461B2

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