2-Chloro-4-t-butylbenzyl alcohol → 4-tert-Butyl-2-chlorobenzaldehyde

HRID 1867245노트

반응식

HRID 1867245 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

4

반응물 1

HCID 688990782-Chloro-4-t-butylbenzyl alcohol

생성물 1

HCID 178596104-tert-Butyl-2-chlorobenzaldehyde수율 79%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

반응 조건

온도
50 °C

실험 절차

The alcohol compound (195 mg, 0.981 mmol) obtained in Step 1-3 was dissolved in chloroform (5 ml). Activated manganese dioxide (1.27 g) was added to the obtained solution, and they were violently stirred at 50° C. for 2 hours. After leaving to cool, manganese dioxide was filtered out, and the filtrate was concentrated under reduced pressure. After the purification by the silica gel column chromatography, 2-chloro-4-t-butylbenzaldehyde (yield: 152 mg, 79%) was obtained.

후처리

  1. customAfter leaving
  2. temperatureto cool
  3. filtrationmanganese dioxide was filtered out
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customAfter the purification by the silica gel column chromatography

출처 및 근거

ORD 기록
ord-fef5663a8e664824a8669e85124167dc
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632830B2

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