Hydrogen Bromide → HCID 136388604, 화합물
반응식
[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][F:19])=[CH:12][C:11]=3[O:20]C)[CH:8]=[CH:9][C:2]=12.Br>C(O)(=O)C>[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][F:19])=[CH:12][C:11]=3[OH:20])[CH:8]=[CH:9][C:2]=12참가 물질
4
실험 절차
10 mg (0.03 mmol) of (4-benzo[1,2,5]oxadiazol-5-yl-3-methoxy-phenyl)-(2-fluoro-ethyl)-amine are dissolved in 0.3 mL acetic acid and 0.3 mL hydrobromic acid (33% in acetic acid) and stirred at 80 QC for 72 h. Then the solvents are removed. The mixture of starting material and desired product can be separated by HPLC (20 to 100% CH3CN/H2O (6′), 100% CH3CN (1.5°), 100 to 20% CH3CN/H2O (0.5°): product elutes after 4.5°). MS(ES+): 274 (M+1).
후처리
- customThen the solvents are removed