Hydrochloric Acid → 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-pyrazole-3-carbohydrazide

HRID 1867562노트

반응식

HRID 1867562 반응식
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=3[Cl:21])[N:12]=[C:11]([C:22]([NH:24][NH:25]C(OC(C)(C)C)=O)=[O:23])[C:10]=2[CH3:33])=[CH:5][CH:4]=1>CO>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=3[Cl:21])[N:12]=[C:11]([C:22]([NH:24][NH2:25])=[O:23])[C:10]=2[CH3:33])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86618350tert-Butyl 2-[[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl]hydrazinecarboxylate

생성물 1

HCID 109821545-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-pyrazole-3-carbohydrazide수율 82.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

20 ml of 2N ethereal hydrochloric acid are added to a solution of 6.2 g of the compound obtained in stage B in 100 ml of MeOH and then the mixture is heated at 40° C. for 3 hours. The reaction mixture is concentrated under vacuum, the residue is extracted with ether, the organic phase is washed twice with a 10% NaHCO3 solution and dried over MgSO4, and the solvent is evaporated under vacuum. The residue is taken up in pentane and the precipitate formed is filtered off. 4.09 g of the expected compound are obtained.

후처리

  1. concentrationThe reaction mixture is concentrated under vacuum
  2. extractionthe residue is extracted with ether
  3. washthe organic phase is washed twice with a 10% NaHCO3 solution
  4. dry with materialdried over MgSO4
  5. customthe solvent is evaporated under vacuum
  6. customthe precipitate formed
  7. filtrationis filtered off

출처 및 근거

ORD 기록
ord-c06cd43da6e04963bf8faca7d93108f7
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632852B2

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