Lithium Hydroxide → HCID 11671386, 화합물

HRID 1867625노트

반응식

HRID 1867625 반응식
[OH-].[Li+].[O:3]=[C:4]1[NH:8][C:7]([C:9]([O:11]C)=[O:10])=[CH:6][N:5]1[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([NH:21][C@@H:22]2[N:28]=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]=3[N:24]([CH2:39][C:40]([F:43])([F:42])[F:41])[C:23]2=[O:44])=[O:20])[CH2:15][CH2:14]1>O.CO>[O:3]=[C:4]1[NH:8][C:7]([C:9]([OH:11])=[O:10])=[CH:6][N:5]1[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([NH:21][C@@H:22]2[N:28]=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]=3[N:24]([CH2:39][C:40]([F:43])([F:42])[F:41])[C:23]2=[O:44])=[O:20])[CH2:15][CH2:14]1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 11519899HCID 11519899, 화합물

생성물 1

HCID 11671386HCID 11671386, 화합물수율 17.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Lithium hydroxide (43 mg, 1.03 mmol) in water (2 mL) was added to a solution methyl 2-oxo-1-[1-({[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]amino}carbonyl)piperidin-4-yl]-2,3-dihydro-1H-imidazole-4-carboxylate (30 mg, 0.051 mmol) in methanol (2 mL) and heated to 40 o C. After 2 h, the reaction was purified by preparative reverse phase chromatography to give the title compound (5 mg). MS 571.2 (M+1)

후처리

  1. temperatureheated to 40 o C
  2. customthe reaction was purified by preparative reverse phase chromatography

출처 및 근거

ORD 기록
ord-91151eaa579e4544a6666d159101a2d5
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632832B2

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