Aniline → Pyrimido(5,4-d)pyrimidine
반응식
NC1C=CC=CC=1.Cl[C:9]1[N:10]=[C:11](Cl)[C:12]2[N:17]=[C:16](Cl)[N:15]=[C:14](Cl)[C:13]=2[N:20]=1>C(Cl)(Cl)Cl>[N:17]1[C:12]2[CH:11]=[N:10][CH:9]=[N:20][C:13]=2[CH:14]=[N:15][CH:16]=1참가 물질
4
실험 절차
8.7 mL (95 mmol) of aniline may be slowly added dropwise to a solution of 4 g (19 mmol) of 2,4,6,8-tetrachloropyrimidopyrimidine in 50 mL of chloroform in a water bath at about 0° C. The results of the reaction may be verified by thin layer chromatography (TLC). The reaction mixture may be washed with an aqueous ammonium chloride solution and extracted with chloroform. The organic layer may be separated, distilled under reduced pressure to remove the solvent, and dried in an oven to yield approximately 5 g of Compound 5a. Compound 5a may be a substantially pale yellow solid.
후처리
- customThe results of the reaction
- washThe reaction mixture may be washed with an aqueous ammonium chloride solution
- extractionextracted with chloroform
- customThe organic layer may be separated
- distillationdistilled under reduced pressure
- customto remove the solvent
- customdried in an oven
출처 및 근거
- ORD 기록
- ord-80ecc067189e4267a4fab8d5cf886adf
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07632947B2
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