Diisopropylethylamine → 2-{4-[(4-Chlorophenyl)sulfonyl]piperidin-1-yl}-5-(trifluoromethyl)pyridine

HRID 1868060노트

반응식

HRID 1868060 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl[C:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][N:19]=1.CCN(C(C)C)C(C)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH:11]2[CH2:16][CH2:15][N:14]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][N:19]=3)[CH2:13][CH2:12]2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 27610724-[(4-Chlorophenyl)sulfonyl]piperidine

생성물 1

HCID 685498862-{4-[(4-Chlorophenyl)sulfonyl]piperidin-1-yl}-5-(trifluoromethyl)pyridine수율 73%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Using the procedure from Example 7A, 4-[(4-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2-chloro-5-(trifluoromethyl)pyridine (138 mg, 0.76 mmol), DIEA (0.27 ml, 1.52 mmol) and 1,4-dioxane (0.3 ml) at 190° C. to afford the title compound (112 mg), a white solid, in 73% yield.

출처 및 근거

ORD 기록
ord-742800db7f884f43bf40ec383dd54986
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632838B2

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