Dichloromethane → 2,6-Bis(chloromethyl)-4-methylphenol

HRID 1868528노트

반응식

HRID 1868528 반응식
O[CH2:2][C:3]1[C:8]([OH:9])=[C:7](CO)[CH:6]=[C:5]([CH3:12])[CH:4]=1.O=S(Cl)[Cl:15].[CH2:17]([Cl:19])Cl>>[Cl:15][CH2:2][C:3]1[C:8]([OH:9])=[C:7]([CH2:17][Cl:19])[CH:6]=[C:5]([CH3:12])[CH:4]=1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 70392,6-Dimethylol-p-cresolHCID 24386Thionyl Chloride

생성물 1

HCID 221462,6-Bis(chloromethyl)-4-methylphenol

실험 절차

2,6-Bis(hydroxymethyl)-p-cresol (0.6779 g, 4.03 mmol) was suspended in CH2Cl2 (10 ml), and to this suspension was added slowly SOCl2 (3 ml, 41.1 mmol) under cooling in an ice-bath, and the resulting mixture was stirred at room temperature for 18 hours. The color of the reaction solution turned yellow. After completion of the reaction, the solvent was removed by evaporation to give 2,6-bis(chloromethyl)-p-cresol.

후처리

  1. temperatureunder cooling in an ice-bath
  2. customAfter completion of the reaction
  3. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-80d1497d8d804bc585bc7e76c5feae3e
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635776B2

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