Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methoxybenzenesulfonyl chloride → 5-Bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| 반응물 | 5-Bromo-7-nitroindoline | HCID 3018911 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 5-Bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline | HCID 68612665 | 85% |
반응 단계
A solution of 5-bromo-7-nitroindoline (5 g, 0.021 mol), 4-methoxyphenylsulfonyl chloride (6.36 g, 0.030 mol) in pyridine (10 ml) was stirred at 120° C. for 16 h. The reaction was quenched with water and extracted with CH2Cl2. The combined organic layer was dried over anhydrous MgSO4 and evaporated to give a residue that was chromatographed over silica gel (EtOAc:n-hexane=1:2) to afford compound 17, yield 85%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741495B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-c280e75b82b44a2190f44874a4c04dbc |
| 출처 메모 | uspto-grants-2010_06 |