Benzimidazole → HCID 178495389, 화합물

HRID 1869609노트

반응식

HRID 1869609 반응식
[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].N1C2C=CC=CC=2NC=1.[OH-].[Na+:36]>C(OC(=O)C)C.N>[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[N-:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[Na+:36]

참가 물질

7

반응물 3

HCID 5798BenzimidazoleHCID 14798Sodium HydroxideHCID 178495390HCID 178495390, 화합물2회

생성물 2

HCID 178495389HCID 178495389, 화합물HCID 178495390HCID 178495390, 화합물

시약·촉매·용매 2

HCID 222Ammonia용매HCID 8857Ethyl Acetate용매

실험 절차

PCT Application PCT/GB2004/000064 and International Publication Number WO 2004/063188 A1, discloses the preparation of rabeprazole and benzimidazole type of compounds. Accordingly, rabeprazole base is prepared by oxidation using sodium hypohalites and isolated. Rabeprazole sodium is prepared by dissolving rabeprazole base in ethylacetate and methanolic ammonia mixture to which methanolic sodium hydroxide is added. The solvent is distilled and rabeprazole sodium is isolated from ethylacetate and n-heptane/n-hexane mixture.

후처리

  1. customisolated
  2. customRabeprazole sodium is prepared
  3. additionis added
  4. distillationThe solvent is distilled

출처 및 근거

ORD 기록
ord-01389cdce6cb4e38ac51b1c46ea960b8
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638633B2

반응 노트

불러오는 중…