Diethyl Ether → Methyl 2-fluoro-6-methoxybenzoate
반응식
[F:1][C:2]1[CH:3]=CC=[C:6](O)[C:7]=1C(O)=O.[C:12](=[O:15])([O-])[O-:13].[K+].[K+].[CH3:18]I.C[CH2:21][O:22][CH2:23][CH3:24]>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][CH:24]=[C:23]([O:22][CH3:21])[C:3]=1[C:12]([O:13][CH3:18])=[O:15]참가 물질
6
실험 절차
To a solution of 6-fluorosalicylic acid (5.00 g) in dimethylformamide (50 ml) was added anhydrous potassium carbonate (6.00 g) and methyl iodide (6.0 ml) with stirring at room temperature, then followed by vigorous stirring at room temperature for 12 hours. After the completion of the reaction, the reaction mixture was diluted by ether, washed with water and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure, to give the title compound (5.80 g, 98%) as an oil.
후처리
- stirringby vigorous stirring at room temperature for 12 hours
- customAfter the completion of the reaction
- washwashed with water
- dry with materialdried over anhydrous sodium sulphate
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-935de1b4a8f04f918dc13c7dd07bd8d3
- 출처 데이터셋
- uspto-grants-2000_08
- 특허 번호
- US06096771
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