HCID 10826647, 화합물 → HCID 15480019, 화합물
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][C:8]([C:12]([O:14]C)=[O:13])=[CH:7][C:6]=2[CH:16]=1>CO.C1COCC1.[OH-].[Na+]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][C:8]([C:12]([OH:14])=[O:13])=[CH:7][C:6]=2[CH:16]=1참가 물질
5
실험 절차
A mixture of methyl 2-bromo-6,7-dihydro-5H-benzocyclohepten-8-carboxylate (1.0 g) in methanol (25 ml), THF (25 ml) and 1N NaOH (18 ml) was refluxed for 1 hour. The solvent was concentrated, acidified using 1N HCl, and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over MgSO4. The solvent was evaporated in vacuo to give 2-bromo-6,7-dihydro-5H-benzocyclohepten-8-carboxylic acid (0.95 g) as colorless prisms.
후처리
- temperaturewas refluxed for 1 hour
- concentrationThe solvent was concentrated
- extractionextracted with ethyl acetate
- washThe organic layer was washed with water and brine
- dry with materialdried over MgSO4
- customThe solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-43d63127e7234bb398ca4b2f41717154
- 출처 데이터셋
- uspto-grants-2000_08
- 특허 번호
- US06096780
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