Phosphorus oxychloride → Butyl 6-chloropyridazine-3-carboxylate
반응식
P(Cl)(Cl)([Cl:3])=O.O=[C:7]1[NH:12][N:11]=[C:10]([C:13]([O:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:14])[CH:9]=[CH:8]1>C(#N)C.O>[Cl:3][C:7]1[N:12]=[N:11][C:10]([C:13]([O:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:14])=[CH:9][CH:8]=1참가 물질
5
실험 절차
To a mixture of phosphorus oxychloride (20 ml) and acetonitrile (40 ml) heated at reflux was added a solution of n-butyl 6-oxo-1,6-dihydropyridazine-3-carboxylate (20 g) in acetonitrile (80 ml). The reaction was heated at reflux for 30 minutes, cooled and added to an ice cooled solution of K2C03 (87.8 g) in water (600 ml) with vigorous stirring. The product was filtered off, washed with water and dried at 60° C. to give n-butyl 6-chloropyridazine-3-carboxylate (17.5 g, 80% yield), mpt 110-111° C.
후처리
- temperatureheated
- temperatureat reflux
- temperatureThe reaction was heated
- temperatureat reflux for 30 minutes
- temperaturecooled
- filtrationThe product was filtered off
- washwashed with water
- customdried at 60° C.
출처 및 근거
- ORD 기록
- ord-87eff584b3e146b9828cd7e6cb639779
- 출처 데이터셋
- uspto-grants-2000_08
- 특허 번호
- US06100258
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