Diethyl Ether → 2-(2-Ethoxyphenyl)ethanol

HRID 1870971

반응식

HRID 1870971 반응식
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].C(=O)([O-])[O-].[K+].[K+].I[CH2:18][CH3:19].CCOCC>CN(C)C=O>[CH2:18]([O:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6])[CH3:19]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 822002-(2-Hydroxyethyl)phenol

생성물 1

HCID 2512712-(2-Ethoxyphenyl)ethanol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
42.5 °C

실험 절차

To a suspension of 1.00 g (7.24 mmol) of 2-hydroxyphenethyl alcohol and 1.35 g (8.68 mmol) of potassium carbonate in 15 ml of N,N-dimethylformamide was added 2.00 g (14.48 mmol) of iodoethane at 0° C. The reaction mixture was stirred at 40-45° C. for 12 h and was poured into 200 ml of ether. It was washed with water (20 ml ×3), dried over MgSO4 and concentrated. The residue was purified by silica gel chromatography with 9:1 hexane/ethyl acetate to afford the 2-ethoxyphenethyl alcohol as a colorless oil.

후처리

  1. washIt was washed with water (20 ml ×3)
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated
  4. customThe residue was purified by silica gel chromatography with 9:1 hexane/ethyl acetate

출처 및 근거

ORD 기록
ord-8cfe1624b0fb47a3a4b9accfc740c1fe
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06100293

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