Sodium Hydroxide → HCID 54529682, 화합물

HRID 1871634노트

반응식

HRID 1871634 반응식
[C:1]1([NH:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][O:24][N:25]=[C:26]([C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:30][CH:29]=3)[CH3:27])=[CH:17][CH:16]=2)[C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([NH:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][O:24][N:25]=[C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:32][CH:33]=3)[CH3:27])=[CH:17][CH:16]=2)[C:9]([OH:11])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 54509846HCID 54509846, 화합물

생성물 1

HCID 54529682HCID 54529682, 화합물수율 91%

실험 절차

The reaction was carried out according to Example 4 using 260 mg of ethyl 2-phenylamino-3-[4-[2-[[1-[4-(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate obtained in Example 5 and 1.00 ml of a 1N aqueous sodium hydroxide solution. After the reaction, the reaction mixture was concentrated and diluted with water. The pH of the reaction mixture was adjusted to a value of 4 with 1N hydrochloric acid, and precipitate was obtained by filtration. The precipitate was washed with water and isopropyl ether to obtain 224 mg of the desired compound.

후처리

  1. customAfter the reaction
  2. concentrationthe reaction mixture was concentrated
  3. additiondiluted with water
  4. customprecipitate was obtained by filtration
  5. washThe precipitate was washed with water and isopropyl ether

출처 및 근거

ORD 기록
ord-76016bf15f0043619959616f3f07e94e
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06103907

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