Hydrochloric Acid → N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide

HRID 1871816

반응식

HRID 1871816 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1.Cl>N1C=CC=CC=1>[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([NH:1][C:2]2[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=2[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:5])(=[O:24])=[O:23])=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 73974-Toluenesulfonyl chlorideHCID 760802-Aminobenzophenone

생성물 1

HCID 233206N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide수율 82.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred solution of 15.0 g of 2-aminobenzophenone in 7.5 cc of pyridine was added 14.5 g of p-toluenesulfonyl chloride under ice-cooling. And the resulting mixture was stirred at room temperature for 16 hours. 2N HCl was added to the reaction mixture and extracted with ethyl acetate. The extract was washed with water and dried over magnesium sulfate. The solvent was distilled off and the crude crystals thus obtained were recrystallized from isopropanol to obtain 22.0 g of compound H. Yield: 82.4%.

후처리

  1. temperaturecooling
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. dry with materialdried over magnesium sulfate
  5. distillationThe solvent was distilled off
  6. customthe crude crystals thus obtained
  7. customwere recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-31048ac6f0534b82afa9b9aa538cfa5f
출처 데이터셋
uspto-grants-2000_08
특허 번호
USRE036832

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