Water → 1-(Bromomethyl)-3-ethylbenzene

HRID 1871982

반응식

HRID 1871982 반응식
P(Br)(Br)[Br:2].[CH2:5]([C:7]1[CH:8]=[C:9]([CH2:13]O)[CH:10]=[CH:11][CH:12]=1)[CH3:6].O>C1C=CC=CC=1>[Br:2][CH2:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([CH2:5][CH3:6])[CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 104659(3-Ethylphenyl)methanol

생성물 1

HCID 220036561-(Bromomethyl)-3-ethylbenzene

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Phosphorous tribromide (5.3 ml) was added to a solution of the product from step (i) (7.6 g) in benzene (150 ml) at 0° C. After 3 hours, water (40 ml) was added and the mixture warmed to room temperature and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 2% ethyl acetate in isohexane. Yield 8.0 g.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated
  4. customPurified by chromatography
  5. washeluting with 2% ethyl acetate in isohexane

출처 및 근거

ORD 기록
ord-b501f9e1eb8544469e9e0de14223e35f
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107297

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