Water → HCID 178435472, 화합물

HRID 1871993노트

반응식

HRID 1871993 반응식
[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[S:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].O.[C:28](=O)(O)[O-].[Na+].IC>C(O)C>[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:28])=[N:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689767HCID 18689767, 화합물

생성물 1

HCID 178435472HCID 178435472, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The product of step (iii) (0.58 g) was dissolved in ethanol (30 ml) and water (5 ml) and treated with sodium bicarbonate(0.14 g) and iodomethane (0.2 ml) and stirred for 24 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic phase was dried (MgSO4) and solvent evaporated under reduced pressure. The residue was triturated with isohexane and filtered to give the product. Yield 0.41 g.

후처리

  1. customThe reaction mixture was partitioned between ethyl acetate and brine
  2. dry with materialThe organic phase was dried (MgSO4) and solvent
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with isohexane
  5. filtrationfiltered
  6. customto give the product

출처 및 근거

ORD 기록
ord-fb51028a58cd4abbb2c17d5c242e8c7b
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107297

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