Methyl iodide → HCID 178503573, 화합물

HRID 1871998노트

반응식

HRID 1871998 반응식
IC.[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19](=[S:25])[NH:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1.[C:28](=O)(O)[O-].[Na+]>C(O)C.O>[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19]([S:25][CH3:28])=[N:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689719HCID 18689719, 화합물

생성물 1

HCID 178503573HCID 178503573, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Iodomethane (0.2 ml) was added to a stirred suspension of the product from step (i) (0.65 g) and sodium bicarbonate (0.4 g) in ethanol (15 ml) and water (4 ml). After stirring for 30 min, the reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water, dried (MgSO4) and evaporated under reduced pressure. The residue was triturated with ether and filtered. Yield 0.49 g.

후처리

  1. washthe reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with ether
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-19a02dd9780f4f77a7f4c8e0c691c1ba
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107297

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