Dimethylamine, hydrochloride → (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester

HRID 1872125

반응식

HRID 1872125 반응식
Cl.[CH3:2][NH:3][CH3:4].[CH3:5][C:6]([O:9][C:10]([NH:12][CH:13]([C:20]([OH:22])=O)[CH2:14][C:15]1[N:19]=[CH:18][S:17][CH:16]=1)=[O:11])([CH3:8])[CH3:7]>>[C:6]([O:9][C:10](=[O:11])[NH:12][C@H:13]([C:20](=[O:22])[N:3]([CH3:4])[CH3:2])[CH2:14][C:15]1[N:19]=[CH:18][S:17][CH:16]=1)([CH3:5])([CH3:7])[CH3:8]

참가 물질

3

반응물 2

HCID 10473Dimethylamine, hydrochlorideHCID 145403222-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid

생성물 1

HCID 54383962(s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester

실험 절차

Dimethylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature) and the product purified by chromatography on silica gel eluted with 1-16% ethanol in dichloromethane containing 0.5% ammonium hydroxide. Yield 124 mg, 41%.

후처리

  1. customthe product purified by chromatography on silica gel
  2. washeluted with 1-16% ethanol in dichloromethane containing 0.5% ammonium hydroxide

출처 및 근거

ORD 기록
ord-2631e8ec6d0c434798a7eec8c0cb97a8
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107329

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