3-Cyanopyridine → 3,4-Dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine

HRID 1872546

반응식

HRID 1872546 반응식
[NH2:1][C:2]1[S:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=O.[C:13]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)#[N:14].Cl>O1CCOCC1>[O:9]=[C:7]1[NH:14][C:13]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:1][C:2]2[S:3][C:4]([CH3:12])=[CH:5][C:6]1=2

참가 물질

5

반응물 3

HCID 793-CyanopyridineHCID 313Hydrochloric AcidHCID 4062885Ethyl 2-Amino-5-methylthiophene-3-carboxylate

생성물 1

HCID 232879063,4-Dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine수율 95.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5 g of 2-amino-5-methyl-3-ethoxycarbonylthiophene together with 2.7 g of 3-cyanopyridine are dissolved in 40 ml of dioxane. Then, gaseous HCl is passed through the solution for 5 hours. After customary workup, 6 g of 3,4-dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine are obtained.

출처 및 근거

ORD 기록
ord-1ee565c856da4d75ba90f1cced5233ce
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06110920

연결된 노트

불러오는 중…