Sodium Sulfide → HCID 178433544, 화합물
반응식
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:5]([C:16]#[N:17])=[C:4]([CH3:18])[N:3]=1.[S-2:19].[Na+].[Na+]>CN(C=O)C>[CH3:18][C:4]1[C:5]([C:16]#[N:17])=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:7]([C:8]#[N:9])=[C:2]([SH:19])[N:3]=1참가 물질
4
실험 절차
471 mg (1.35 mmol) of the compound from Example 40A are initially charged in 4 ml of dry DMF, and 126 mg (1.62 mmol) of sodium sulfide are added. The reaction mixture is stirred at RT for 12 h. The solvent is then removed on a rotary evaporator and the residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1).
후처리
- customThe solvent is then removed on a rotary evaporator
- customthe residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1)
출처 및 근거
- ORD 기록
- ord-b3dc74507d3440e58c399b5a6527ceae
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08304412B2
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