Sulfuric Acid → 4-(Chloromethyl)-2-(4-fluoro-3-methylphenyl)-1,3-oxazole

HRID 1873584노트

반응식

HRID 1873584 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[CH3:11].[Cl:12][CH2:13][C:14]([CH2:16]Cl)=O.S(=O)(=O)(O)O>>[Cl:12][CH2:13][C:14]1[N:8]=[C:6]([C:5]2[CH:9]=[CH:10][C:2]([F:1])=[C:3]([CH3:11])[CH:4]=2)[O:7][CH:16]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 107931,3-DichloroacetoneHCID 27745784-Fluoro-3-methylbenzamide

생성물 1

HCID 582842534-(Chloromethyl)-2-(4-fluoro-3-methylphenyl)-1,3-oxazole

실험 절차

2.00 g (12.80 mmol) of 4-fluoro-3-methylbenzamide and 1.79 g (14.08 mmol) of 1,3-dichloroacetone are stirred at 130° C. for 2 days, resulting in the formation of a melt. The mixture is then cooled to RT, 3.0 ml of conc. sulfuric acid are added carefully at this temperature and the mixture is stirred for 15 min. The suspension obtained is poured into 20 ml of ice-water and stirred at RT overnight. The precipitate formed is filtered off and dried in a vacuum drying cabinet at 40° C. overnight.

후처리

  1. customresulting in the formation of a melt
  2. customThe suspension obtained
  3. stirringstirred at RT overnight
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. customdried in a vacuum
  7. customdrying cabinet at 40° C. overnight

출처 및 근거

ORD 기록
ord-4d7834d0b5a84d53a6b52fe832abbc2b
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304412B2

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