Hydrazine hydrate (1:1) → 5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

HRID 1873792노트

반응식

HRID 1873792 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([C:16](=O)[C:17]([CH3:23])([CH3:22])[C:18](OC)=[O:19])[CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:3][CH2:2]1.O.[NH2:26][NH2:27]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([C:16]3[C:17]([CH3:23])([CH3:22])[C:18](=[O:19])[NH:26][N:27]=3)[CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 66616523Methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate2회

생성물 1

HCID 666164295-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

실험 절차

Prepared analogously as described for example C1 using methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate (compound D3) and hydrazine hydrate as starting compounds.

후처리

  1. customPrepared analogously

출처 및 근거

ORD 기록
ord-246bb6387ebc4c2dae7d5b489e4bf4f8
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304436B2

반응 노트

불러오는 중…