Tert-butyl 3-(6-nitropyridin-3-yloxy)phenylcarbamate → Tert-butyl 3-(6-aminopyridin-3-yloxy)phenylcarbamate

HRID 1874363

반응식

HRID 1874363 반응식
[N+:1]([C:4]1[N:9]=[CH:8][C:7]([O:10][C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-])=O>[C].[Pd].CO>[NH2:1][C:4]1[N:9]=[CH:8][C:7]([O:10][C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 57749209Tert-butyl 3-(6-nitropyridin-3-yloxy)phenylcarbamate

생성물 1

HCID 57749334Tert-butyl 3-(6-aminopyridin-3-yloxy)phenylcarbamate수율 106.6%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

In the same manner as in Reference Example 34 and using tert-butyl {3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate (16.4 g, 49.5 mmol), palladium carbon (50% water-containing product, 1.50 g) and methanol (100 mL) as starting materials, the title compound (15.9 g, quant.) was obtained as a yellow oil.

출처 및 근거

ORD 기록
ord-a02cc20b73f54b1aa2c9721bf3bc5b73
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304557B2

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