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18-Crown-6 → 3-Chloro-5-[(2-chloro-6-fluoro-3-methylphenyl)oxy]benzonitrile

HRID 1875126
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HRID 1875126 반응식
C(O[K])(C)(C)C.[Cl:7][C:8]1[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]([F:15])[C:9]=1[OH:16].[Cl:17][C:18]1[CH:19]=[C:20]([CH:23]=[C:24](F)[CH:25]=1)[C:21]#[N:22].C1OCCOCCOCCOCCOCCOC1>CS(C)=O>[Cl:17][C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([O:16][C:9]2[C:10]([F:15])=[CH:11][CH:12]=[C:13]([CH3:14])[C:8]=2[Cl:7])[CH:25]=1)[C:21]#[N:22]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 2855718-Crown-6HCID 27348413-Chloro-5-fluorobenzonitrileHCID 27736832-Chloro-6-fluoro-3-methylphenolHCID 178418922HCID 178418922, 화합물

생성물 1

HCID 684836723-Chloro-5-[(2-chloro-6-fluoro-3-methylphenyl)oxy]benzonitrile수율 79.4%

시약·촉매·용매 1

HCID 679
Dimethyl Sulfoxide
용매

실험 절차

The title compound was prepared as described herein using tBuOK (4.00 ml, 4.00 mmol), 2-chloro-6-fluoro-3-methylphenol (642 mg, 4.00 mmol), 3-chloro-5-fluorobenzonitrile (622 mg, 4.00 mmol) and 18-crown-6 (211 mg, 0.800 mmol) in dimethyl sulfoxide (16 ml) to give the title compound as a white solid (0.94 g, 79%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.33 (1H, s) 7.12-7.19 (2H, m) 7.07 (1H, t, J=8.9 Hz) 6.98 (1H, s) 2.40 (3H, s). LCMS: m/z 294 (M−1).

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-cc3c4422d20d44658b0acbe8155696a1
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08304419B2

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