5-(2,4-Difluorophenyl)-2-methyl-3-furaldehyde → Cyclohexyl[5-(2,4-difluorophenyl)-2-methyl-3-furyl]methanol

HRID 1876967

반응식

HRID 1876967 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:13][C:12]([CH3:14])=[C:11]([CH:15]=[O:16])[CH:10]=1.[CH:17]1([Mg]Br)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.O1CCCC1>>[CH:17]1([CH:15]([C:11]2[CH:10]=[C:9]([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[F:1])[O:13][C:12]=2[CH3:14])[OH:16])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 835956455-(2,4-Difluorophenyl)-2-methyl-3-furaldehydeHCID 178420632HCID 178420632, 화합물

생성물 1

HCID 68515112Cyclohexyl[5-(2,4-difluorophenyl)-2-methyl-3-furyl]methanol수율 76%

실험 절차

An operation similar to that in Example 3 (2) was performed using 5-(2,4-difluorophenyl)-2-methyl-3-furaldehyde (2.4 g) and 1N cyclohexylmagnesium bromide-tetrahydrofuran solution (16.5 mL) to give the title compound (2.6 g, 76%) as a white crystal.

출처 및 근거

ORD 기록
ord-11bb2b91221f40989159f4c2f696dd35
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

연결된 노트

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