1,2,3,4-Tetrahydroquinoline → HCID 46194987, 화합물

HRID 1877364노트

반응식

HRID 1877364 반응식
ClC1C=CC(Cl)=CC=1OC1N=CC=CC=1C(O)=O.[Cl:19][C:20]1[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:21]=1[O:22][C:23]1[N:31]=[CH:30][CH:29]=[CH:28][C:24]=1[C:25]([OH:27])=O.F[C:38]1[CH:39]=[C:40]2[C:45](=[CH:46][CH:47]=1)[NH:44][CH2:43][CH2:42][CH2:41]2.N1C2C(=CC=CC=2)CCC1>>[Cl:19][C:20]1[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:21]=1[O:22][C:23]1[C:24]([C:25]([N:44]2[C:45]3[C:40](=[CH:39][CH:38]=[CH:47][CH:46]=3)[CH2:41][CH2:42][CH2:43]2)=[O:27])=[CH:28][CH:29]=[CH:30][N:31]=1

참가 물질

5

반응물 4

HCID 694601,2,3,4-TetrahydroquinolineHCID 2158923-Pyridinecarboxylic acid, 2-(2,4-dichlorophenoxy)-HCID 147839116-Fluoro-1,2,3,4-tetrahydroquinolineHCID 167959962-(2,5-Dichloro-phenoxy)-nicotinic acid

생성물 1

HCID 46194987HCID 46194987, 화합물

실험 절차

The title compound was prepared in analogy to Example 37 replacing 2-(2,5-dichloro-phenoxy)-nicotinic acid with 2-(2,4-dichloro-phenoxy)-nicotinic acid and 6-fluoro-1,2,3,4-tetrahydro-quinoline with 1,2,3,4-tetrahydro-quinoline ([CAS RN 635-46-1]). MS (ISP): 399.0 [M+H]+.

출처 및 근거

ORD 기록
ord-3657726926314125a5c98ff6478b2820
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309734B2

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