Under exclusion of oxygen, 17.2 mg (0.09 mmol) of EDC and 11.7 mg (0.09 mmol) of HOBt and 8.3 mg (0.18 mmol) of formic acid are added to a solution of 35.0 mg (0.07 mmol) of 1-{[1-(3-chlorophenyl)-5-(3-trifluoromethylthiophenyl)-1H-pyrazol-3-yl]carbonyl}piperazine, prepared from the compound of example 8A and piperazine in analogy to example 1, in 1 ml DMF, and the mixture is stirred for 72 hours at room temperature. The reaction mixture is separated by preparative HPLC. 15.7 mg (42% yield of theory) of product are obtained.
