Chloroacetyl chloride → HCID 44574259, 화합물
반응식
C(N(CC)CC)C.[Cl:8][CH2:9][C:10](Cl)=[O:11].[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]#[N:21])=[N:18][CH:19]=1>C(Cl)(Cl)Cl>[Cl:8][CH2:9][C:10]([NH:13][C:14]1[CH:19]=[N:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=1)=[O:11]참가 물질
5
실험 절차
Triethylamine (0.50 g, 4.9 mmol) and chloroacetyl chloride (0.56 g, 4.9 mmol) were added dropwise at 0° C. to a stirred suspension of 5-Amino-2-cyanopyridine (0.27 g, 2.25 mmol) in chloroform (10 mL). The mixture was stirred at room temperature for 12 hours. The reaction mixture was diluted with chloroform (50 mL) and washed with water (2×50 mL). The organic layer was dried over anhydrous sodium sulfate, concentrated and the crude product obtained was crystallized from chloroform:petroleum ether (1:2) to obtain the title compound.
후처리
- washwashed with water (2×50 mL)
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- concentrationconcentrated
- customthe crude product obtained
- customwas crystallized from chloroform:petroleum ether (1:2)
출처 및 근거
- ORD 기록
- ord-330541eb80f547aaa39f078fc5085d55
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08314103B2
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