1-(2-Hydroxyethyl)piperazine → HCID 86659721, 화합물

HRID 1878559노트

반응식

HRID 1878559 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.[OH:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:7]=[C:6]([N:24]2[CH2:25][CH2:26][N:21]([CH2:20][CH2:19][OH:18])[CH2:22][CH2:23]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

참가 물질

3

반응물 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 49761343HCID 49761343, 화합물

생성물 1

HCID 86659721HCID 86659721, 화합물

실험 절차

There was dissolved, in 1,4-dioxana (3 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (50.4 mg, 0.191 mM), then 1-(2-hydroxyethyl)-piperazine (46 μL, 0.382 mM) was added to the solution and the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture and the resulting solid was washed with ethyl acetate to thus give the title compound in a quantitative yield.

후처리

  1. distillationThe solvent was distilled off from this reaction mixture
  2. washthe resulting solid was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-a872563a50704455ae358a0b497b1786
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

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