Sodium Hydroxide → 6-Bromo-4-chloro-1H-pyrrolo[2,3-B]pyridine

HRID 1878612노트

반응식

HRID 1878612 반응식
[Br:1][C:2]1[N:7]=[C:6]2[N:8](C(C3C=CC=CC=3)=O)[CH:9]=[CH:10][C:5]2=[C:4]([Cl:19])[CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[C:4]([Cl:19])[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 73014178(6-Bromo-4-chloro-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

생성물 1

HCID 247295876-Bromo-4-chloro-1H-pyrrolo[2,3-B]pyridine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

(6-Bromo-4-chloro-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone (1 eq, 69.7 mmol, 23.4 g) is dissolved in MeOH (300 ml), then aqueous NaOH solution (1 M, 120 ml) is added and the resulting mixture is stirred for 18 h at r.t. The mixture is extracted with DCM and EtOAc, the extracts are combined and the solvents are removed in vacuo. Recrystallization from MeOH yields the title compound; [M+H]+=231.

후처리

  1. extractionThe mixture is extracted with DCM and EtOAc
  2. customthe solvents are removed in vacuo
  3. customRecrystallization from MeOH

출처 및 근거

ORD 기록
ord-34d7a9f803954f57bee3507ac7c79743
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314112B2

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