Sodium Carbonate → HCID 57448056, 화합물

HRID 1879062노트

반응식

HRID 1879062 반응식
[F:1][C:2]([F:19])([F:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])=[O:4].[BH4-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:19][C:2]([F:1])([F:18])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[C:6]=1[F:17])[OH:4]

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 4311764Sodium borohydrideHCID 67532664HCID 67532664, 화합물

생성물 1

HCID 57448056HCID 57448056, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanone (0.045 g, 0.16 mmol) was dissolved in ethanol (10 ml) and sodium borohydride (0.026 g, 0.064 mmol) was added. The resulting mixture was stirred for 24 h, after which aqueous sodium carbonate (10%, 20 ml) was added. The aqueous phase was extracted with ethylacetate (3×20 ml) and the combined organic phases was dried (MgSO4), filtered and evaporated to dryness. Yield: 0.03 g. MS m/z (rel. intensity, 70 eV) 277 (M+, 87), 276 (69), 178 (14), 103 (19), 56 (bp).

후처리

  1. extractionThe aqueous phase was extracted with ethylacetate (3×20 ml)
  2. dry with materialthe combined organic phases was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-604700d3ce15492ba859edc2b48ccb50
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314126B2

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