Sodium Hydroxide → HCID 18441970, 화합물

HRID 1879408노트

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HRID 1879408 반응식
N1C(C([O-])=O)=C[N:4]=[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:2]=1.[OH-:15].[Na+]>C(O)C>[CH2:13]([O:12][C:10]([C:3]1[N:4]=[N:4][C:3]([C:10]([OH:11])=[O:15])=[CH:2][CH:2]=1)=[O:11])[CH3:14]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86656579HCID 86656579, 화합물

생성물 1

HCID 18441970HCID 18441970, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.15 g of ethyl pyrazine-3,6-dicarboxylate was dissolved in 34.5 mL of ethanol, and 5.64 mL of a 1 M aqueous sodium hydroxide solution was added thereto, followed by stirring at room temperature for 3.5 hours. The precipitated salt was collected by filtration and dissolved in a small amount of water, and then this solution was acidified (pH=2) with a 1 M aqueous hydrochloric acid solution, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated to obtain 435 mg of 6-(ethoxycarbonyl)pyridazine-3-carboxylic acid.

후처리

  1. filtrationThe precipitated salt was collected by filtration
  2. dissolutiondissolved in a small amount of water
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-28f0a939f0bb4d59a4260a7dd536615f
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314240B2

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