Phosphorus oxychloride → 3-Chloro-5-phenyl-pyridazine-4-carbonitrile

반응식

O=[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[N:4][NH:3]1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9]

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 597350963-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile

생성물 1

HCID 597350973-Chloro-5-phenyl-pyridazine-4-carbonitrile

반응 조건

온도: 100 °C

실험 절차

3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile (70 mg) was suspended in 1 mL phosphorous oxychloride and heated to 100° C. for 6 hours. The mixture was then cooled and poured onto ice. The resulting brown solid product was filtered and air dried and used in the next step without further purification.

후처리

temperatureThe mixture was then cooled
additionpoured onto ice
filtrationThe resulting brown solid product was filtered
customair dried
customused in the next step without further purification

출처 및 근거

ORD 기록: ord-800015b3b78a43a9babce63e6add21b0
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08318467B2

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